1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-
GSK2636771
CAS: 1372540-25-4
Molecular Formula: C22H22F3N3O3
1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)- - Names and Identifiers
1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)- - Physico-chemical Properties
| Molecular Formula | C22H22F3N3O3 |
| Molar Mass | 433.42 |
| Density | 1.38 |
| Melting Point | >225°C (dec.) |
| Boling Point | 641.3±55.0 °C(Predicted) |
| Solubility | DMSO 28 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | Solid |
| Color | Pale Yellow |
| pKa | -2.70±0.30(Predicted) |
| Storage Condition | -20°C Freezer |
| In vitro study | GSK-2636771 has selective inhibitory activity against PTEN-deficient cell lines (human prostate cancer PC-3 and breast cancer HCC70) with EC50 of 36 nM and 72 nM, respectively. |
| In vivo study | These xenograft models were treated GSK-2636771 to reduce the level of the phosphorylated protein kinase Akt(Ser473). Treatment of mice with GSK-2636771(100 mg/kg) did not increase glucose/insulin levels. |
1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)- - Introduction
GSK2636771 is an orally biopotent PI3Kβ selective inhibitor sensitive to PTEN deletion cell lines.
Last Update：2022-10-16 17:41:27
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View History
1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-
Ethanone, 1-(3',3'-difluoro[1,4'-bipiperidin]-1'-yl)-2,2,2-trifluoro-
安伯莱特离子交换树脂 A26 氢氧型
Benzenamine, 2-ethynyl-4-(1-methylethyl)-
5-[(2-methoxyphenyl)azo]toluene-2,4-diamine hydrochloride
3-乙酰氧基-2-甲基苯甲酸
1-PHENYL-1H-INDOLE-2,3-DIONE 3-[O-(4-FLUOROBENZYL)OXIME]
Benzenediazonium, 4-[(2-methoxyphenyl)azo]-2-methyl-5-[(2-nitro-4-sulfophenyl)amino]-, chloride, reaction products with formaldehyde-salicylic acid polymer
2-CHLORO-N-[1-(2-METHOXYPHENYL)ETHYL]ACETAMIDE
Ethanone, 1-(3',3'-difluoro[1,4'-bipiperidin]-1'-yl)-2,2,2-trifluoro-
安伯莱特离子交换树脂 A26 氢氧型
Benzenamine, 2-ethynyl-4-(1-methylethyl)-
5-[(2-methoxyphenyl)azo]toluene-2,4-diamine hydrochloride
3-乙酰氧基-2-甲基苯甲酸
1-PHENYL-1H-INDOLE-2,3-DIONE 3-[O-(4-FLUOROBENZYL)OXIME]
Benzenediazonium, 4-[(2-methoxyphenyl)azo]-2-methyl-5-[(2-nitro-4-sulfophenyl)amino]-, chloride, reaction products with formaldehyde-salicylic acid polymer
2-CHLORO-N-[1-(2-METHOXYPHENYL)ETHYL]ACETAMIDE